Overview:

Nicotinamide mononucleotide (NMN) is a ribonucleotide containing of the nitrogenous base nicotinamide, a ribose sugar, and a phosphate group (1). NMN is a direct precursor of the coenzyme nicotinamide adenine dinucleotide (NAD)(2). NMN biosynthesis pathways vary in eukaryotes and prokaryotes. NMN plays a role in cardiac and cerebral ischemia, Alzheimer's disease, diabetes, obesity, cancer and aging (3). Scientific applications of this product include pharmacological studies and RNA aptamer binding motif analysis.

References:

1. National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 14180, Nicotinamide mononucleotide. Retrieved October 18, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/Nicotinamide-mononucleotide.

2. Nakamura M, Bhatnagar A, Sadoshima J. Overview of pyridine nucleotides review series. Circ Res. 2012 Aug 17;111(5):604-10. doi: 10.1161/CIRCRESAHA.111.247924. PMID: 22904040; PMCID: PMC3523884.

3. Poddar SK, Sifat AE, Haque S, Nahid NA, Chowdhury S, Mehedi I. Nicotinamide Mononucleotide: Exploration of Diverse Therapeutic Applications of a Potential Molecule. Biomolecules. 2019 Jan 21;9(1):34. doi: 10.3390/biom9010034. PMID: 30669679; PMCID: PMC6359187..