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ACE2 (19-740) Protein

Recombinant human angiotensin-converting enzyme 2 (ACE2) extracellular domain (19-740) was expressed in CHO cells using a C-terminal Fc tag.

A51C2-G341F

50 ug 100 ug

$ 400

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Overview:

The angiotensin converting enzyme 2 (ACE2) belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases (1). ACE2 cleaves the angiotensin I and angiotensin II to counterbalancing ACE activity in the regulation of renin angiotensin system (RAS) (1). ACE2 also has the role in regulation of cardiovascular, renal and reproductive systems (1). In addition, ACE2 is a functional receptor for the spike glycoprotein (S) of SARS-CoV, HCoV-NL63 (2), and SARS-CoV-2, which causes the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (3).


Gene Aliases:

ACEH


Genebank Number:


Formulation:

50mM Tris-HCl, pH 7.5, 90mM glycine.


References:


1. Imai Y, et al: Angiotensin-converting enzyme 2 (ACE2) in disease pathogenesis. Circ J. 2007, 74(3):405-10.

2. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235.

3. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.




There are no related publications available for this product.


RESEARCH AREAS

Acute Respiratory Distress Syndrome , Cardiovascular Disease, Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Infectious Diseases , Inflammation, Lung Diseases , Neurobiology, Ser/Thr Kinases, severe acute respiratory syndrome coronavirus 2 , Virology



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