Recombinant SARS-CoV Spike Protein RBD (318-510) was expressed in CHO cells using a C-terminal human IgG1 Fc tag.
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SARSD-G241F |
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50 ug
100 ug
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$ 290 |
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*The image is illustrative and does not necessarily represent the product
Overview:
The severe acute respiratory syndrome related novel coronavirus (SARS-CoV) has caused the 2002-2003 SARS epidemic that broke out in southern China, which spread to other regions of Asia, Europe and North America (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2). SARS-CoV can specifically recognize ACE2 through its receptor binding domain (RBD) of S1 to initiate viral infection in humans (3).
Gene Aliases:
SARS coronavirus S1, coronavirus S2, coronavirus spike, cov spike, ncov S1, ncov S2, ncov RBD, Spike RBD, RBD.
Genebank Number:
Formulation:
Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 90mM glycine.
References:
1. Li F, et al: Receptor recognition and cross-species infections of SARS coronavirus. Antiviral Research. 2013, 100 (1): 246-254.
2. Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.
3. Wan Y, et al: Receptor Recognition by the novel Coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS Coronavirus. Journal of virology. 2020: 94.
There are no related publications available for this product.
Acute Respiratory Distress Syndrome , Cardiovascular Disease, Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Infectious Diseases , Inflammation, Lung Diseases , Metabolic Disorder, Neurobiology, severe acute respiratory syndrome coronavirus 2 , Virology
SARS-CoV Spike Protein S1, HIS Tag, SARS1-G241H