Overview:

UvsY is a bacteriophage T4 recombination mediator protein (RMP) which promotes homologous recombination. UvsY exists in solution predominantly as a hexamer, and binds to ssDNA in this form. UvsY facilitates assembly of presynaptic filaments by loading UvsX recombinase onto ssDNA and the concomitant displacement of Gp32 ssDNA-binding protein from ssDNA (1,2).

Gene Aliases:

Bacteriophage T4 DNA repair gene uvsY, recombination protein uvsY

Genebank Number:

X04856.1

Formulation:

Recombinant protein stored in 50mM sodium phosphate, pH 7.5, 300mM NaCl, 20% glycerol, 1 mM DTT.

References:

1. Liu, J. et al: Mechanism of presynaptic filament stabilization by the bacteriophage T4 UvsY recombination mediator protein. Biochemistry, 2006; 45(17): 5493–5502. 2. Liu, J. et al: Assembly and dynamics of the bacteriophage T4 homologous recombination machinery. Virol J, 2010; 7:357.