Overview:

Immunoglobulin (Ig) binding protein, Protein G, is present on the surface of group C and G Streptococcal bacteria. Protein G is known to bind the Fab and Fc regions of the antibody in the host cell and suppresses host cell immune responses (1). Such cross-linking is found to prevent opsonophagocytosis and result in B-cell death in vitro (2). All four human IgG subclasses interact with protein G with high affinity (3). Overall, protein G can be used as an immunological reagent in a broad range of studies that involve detection of antibody-secreting cells (4).

Formulation:

Recombinant protein stored in 50mM sodium phosphate, pH 7.5, 300mM NaCl, 200mM imidazole, 1mM DTT, 10% glycerol.