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Single-stranded DNA binding protein

Recombinant full-length E. coli Single-stranded DNA binding protein was expressed in E. coli with an N-terminal His tag.


50 ug 200 ug 500 ug 1000 ug

$ 45


Single-stranded DNA binding protein (SSB) in E. coli is involved in DNA replication, repair, and recombination (1). SSB enhances helix destabilization by DNA helicases thus preventing reannealing of single-stranded DNA and nuclease digestion during DNA replication (1). E. coli SSB is required for methyl-directed mismatch repair, induction of the SOS response, and recombinational repair (1). SSB interacts with DNA helicase RecQ of the RecF-recombination pathway and stimulates helicase activity (2). SSB also stabilizes replication origins, primosome assembly, plays a role in primosome assembly, enhances replication fidelity and polymerase processivity, and promotes polymerase binding to template DNA (1,2).

Gene Aliases:

ssb, exrB, lexC,

Genebank Number:


Recombinant protein stored in 50mM sodium phosphate, pH 8.0, 300mM NaCl, 150mM imidazole, 1mM DTT, 10% glycerol.


1. Meyer, R. R., Laine, P. S. The single-stranded DNA-binding protein of Escherichia coli. Microbiol Rev. 1990, 54(4): 342-380. 2. Shereda, R. D. et al. SSB as an organizer/mobilizer of genome maintenance complexes. Crit Rev Biochem Mol Biol. 2008, 43(5): 289-318.

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Cancer, Cell Cycle